Dr. Wang received his bachelor’s degree (1991) in School of Life Sciences, Fudan University, master’s (1997) and doctor’s degree (2000) in College of Life Sciences, Peking University. Now he is working in Cleveland Clinic as a Staff Scientist, focusing on investigation of pathways linking to atherosclerotic heart disease and other inflammatory diseases. He has reported that myeloperoxidase (MPO) can catalyze the oxidation of thiocyante to cyanate, which can lead to post-translational modification of proteins as carbamylation, and the carbamylated lipoproteins (LDL, HDL) contribute to the development of atherosclerosis (Nat Med. 2007). He also reported that trimethylamine N-oxide (TMAO) metaorganismal pathway contributes to atherosclerotic cardiovascular disease (Nature 2011; N Engl J Med. 2013; Nat Med. 2013) and targeting microbial trimethylamine lyases can attenuate atherosclerosis (Cell. 2015), and that red meat consumption can lead to elevated circulating TMAO compared with non-meat and white meat (Eur Heart J. 2019).
