Guoping Zhao

Dr. Guoping Zhao obtained a bachelor's degree in microbiology from Fudan University in 1982 and a doctoral degree in biochemistry from Purdue University in 1990.

He is Member of the Chinese Academy of Sciences (elected in 2005);

Fellow of the Third World Academy of Sciences (elected in 2011);

Fellow of the American Academy of Microbiology (elected in 2022).

He has been engaged in the research of microbial physiology and biochemistry, metabolic regulation and enzyme mechanisms for many years. He opened up the new frontier of systems synthetic biology and established the CAS Key Laboratory of Synthetic Biology, laying a solid foundation for the synthesis of natural compounds in artificial cell factories, the construction of single-chromosomal yeast and the creation of CRISPR-Dx systems. In recent years, he has participated in the establishment and leadership of Bio-Med Big Data Center of the CAS Shanghai Institute of Nutrition and Health, carrying out preliminary research for the creation of a national comprehensive service platform for biomedical big data.

• W. Dong et al., Mycobacterial fatty acid catabolism is repressed by FdmR to sustain lipogenesis and virulence. Proc Natl Acad Sci U S A 118,  (2021).

• W. Tan et al., A recently evolved diflavin-containing monomeric nitrate reductase is responsible for highly efficient bacterial nitrate assimilation. J Biol Chem 295, 5051-5066 (2020).

• P. Li, H. Zhang, G. P. Zhao, W. Zhao, Deacetylation enhances ParB-DNA interactions affecting chromosome segregation in Streptomyces coelicolor. Nucleic Acids Res 48, 4902-4914 (2020).

• T. Liao, Y. Wei, M. Luo, G. P. Zhao, H. Zhou, tmap: an integrative framework based on topological data analysis for population-scale microbiome stratification and association studies. Genome Biol 20, 293 (2019).

• S. Y. Li et al., CRISPR-Cas12a has both cis- and trans-cleavage activities on single-stranded DNA. Cell Res 28, 491-493 (2018).

• S. Y. Li et al., CRISPR-Cas12a-assisted nucleic acid detection. Cell Discov 4, 20 (2018).

• C. Lei et al., The CCTL (Cpf1-assisted Cutting and Taq DNA ligase-assisted Ligation) method for efficient editing of large DNA constructs in vitro. Nucleic Acids Res 45, e74 (2017).

• G. Liu et al., Long-term strain improvements accumulate mutations in regulatory elements responsible for hyper-production of cellulolytic enzymes. Sci Rep 3, 1569 (2013).

• B. Zhang et al., An efficient procedure for marker-free mutagenesis of S. coelicolor by site-specific recombination for secondary metabolite overproduction. PLoS One 8, e55906 (2013).

• S. Hu et al., Comparative genomic and transcriptomic analysis revealed genetic characteristics related to solvent formation and xylose utilization in Clostridium acetobutylicum EA 2018. BMC Genomics 12, 93 (2011).

• P. Hao et al., Complete sequencing and pan-genomic analysis of Lactobacillus delbrueckii subsp. bulgaricus reveal its genetic basis for industrial yogurt production. PLoS One 6, e15964 (2011).

• Y. X. Wei et al., Complete genome sequence of Bifidobacterium longum JDM301. J Bacteriol 192, 4076-4077 (2010).

• C. Zhang et al., Interactions between gut microbiota, host genetics and diet relevant to development of metabolic syndromes in mice. ISME J 4, 232-241 (2010).

• Q. Wang et al., Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux. Science 327, 1004-1007 (2010).

• X. Ou, B. Zhang, L. Zhang, G. Zhao, X. Ding, Characterization of rrdA, a TetR family protein gene involved in the regulation of secondary metabolism in Streptomyces coelicolor. Appl Environ Microbiol 75, 2158-2165 (2009).

• Z. Y. Zhang et al., Complete genome sequence of Lactobacillus plantarum JDM1. J Bacteriol 191, 5020-5021 (2009).

• M. Li et al., Symbiotic gut microbes modulate human metabolic phenotypes. Proc Natl Acad Sci U S A 105, 2117-2122 (2008).
  

• S. X. Ren et al., Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing. Nature 422, 888-893 (2003).