Wei Wang

Feb. 2023- Present       Associate Professor, P.I., School of Life Sciences, Fudan University
Nov. 2017- Jan. 2023   Assistant, Associate Professor, Shanghai Jiao Tong University School of Medicine
Apr. 2015–Nov. 2017    Postdoctoral fellow, Peking University   

Millions of chemical and biochemical reactions, in which microbes are involved, occur constantly in our gut, and yet our knowledge of these processes is still far from sufficient. Aiming to elucidate these reactions and processes, we pioneer new chemical tools and strategies that are suitable for in vivo research and capable of directly probing microbiota in situ. By integrating these chemical tools with advanced imaging, bioinformatic and multi-omics analysis, we hope to bring new insights of the microbial “dark matter” in our gut via this “chemical microbiomics” approach.

1. Du Y.#, Wang Y.#, Yang M., Lin L., Zhang J., Huang Z., Liu C., Liu S., Ma J.*, Yang C.*, Wang W.* (2025) Unusual MurC ligase and peptidoglycan discovered in Lachnospiraceae using a fluorescent L-amino acid based selective labeling probe. Angew. Chem. Int. Ed., DOI, 10.1002/anie.202503049.

2. Fan X.#, Zhou Y.#, Bai W.#, Li X., Lin L., Lin H., Yang M., Yu X., Wang J.*, Lin L.,* Wang W.* (2025) Intravital imaging of translocated bacteria via fluorogenic labeling of gut microbiota in situ. Proc. Natl. Acad. Sci., 122, e2415845122.

3. Du Y.#, Zhou Y.#,*, Lin H., Yang C.*, Wang W.*, (2025) Three-dimensional imaging of native microbiota in intact colon. Anal. Chem., 97, 6571.

4. Lin H., Zheng X., Lin L., Yang C.*, Wang W.* (2025) Revealing NOD1-activating Gram-positive gut microbiota via in vivo labeling with a meso-diaminopimelic acid probe. ACS Chem. Biol., 20, 62.

5. Zhou Y., Lin L., Wang W.* (2024) An integrative approach for imaging and quantitative analysis of gut microbiota growth in vivo using fluorescent D-amino acid labeling and fluorescence in situ hybridization. Biophys. Rep., DOI: 10.52601/bpr.2024.240044.

6. Li Y., Zhou Y., Du Y., Gao P., Yang L., Wang W.* (2024) In vivo labeling and intravital imaging of bacterial infection using a near-infrared fluorescent D-amino acid probe. ChemBioChem, 25, e202400283.

7. Xu N.*, Lin H., Lin L., Tang M., Zhang Z., Yang C.*, Wang W.* (2024) Visual and quantitative analysis of dietary fiber-microbiota interactions via metabolic labeling in vivo. ChemBioChem, 25, e202400922.

8.    Chen D.#, Guo J.#, Li A., Sun C., Lin H., Lin H.*, Yang C.*, Wang W.*, Gao J.* (2023) Metabolic fluorine labeling and hotspot imaging of dynamic gut microbiota in mice. Sci. Adv., 9, eabg6808.

9.    Xu N.#, Lin L.#, Du Y., Lin H., Song J., Yang C.*, Wang W.* (2022) Visualizing and assessing the germination of microbiota endospores in the mammalian gut. Gut Microbes, 14, 2125737.

10.    Gao J.#, Sun D.#, Li B., Yang C.*, Wang W.* (2022) Integrated identification of growth pattern and taxon of bacterium in gut microbiota via confocal fluorescence imaging-oriented single-cell sequencing. mLife, 1, 358.

11.    Lin L., Du Y., Song J., Wang W.*, Yang C.* (2021) Imaging commensal microbiota and pathogenic bacteria in the gut. Acc. Chem. Res., 54, 2076.

12.    Wang W.#,*, Zhang N.#, Du Y.#, Gao J., Li M., Lin L., Czajkowsky D.M., Li X.*, Yang C.*, Shao Z. (2021). Three-dimensional quantitative imaging of native microbiota distribution in the gut. Angew. Chem. Int. Ed., 60, 3055.

13.    Lin L., Wu Q., Song J., Du Y., Gao J., Song Y., Wang W.*, Yang C.* (2020). Revealing the in vivo growth and division patterns of mouse gut bacteria. Sci. Adv., 6, eabb2531.

14.    Lin L., Song J., Du Y., Wu Q., Gao J., Song Y., Yang C.*, Wang W.* (2020). Quantification of bacterial metabolic activities in the gut by D-amino acid-based in vivo labeling. Angew. Chem. Int. Ed., 59, 11923.