Hao Wu

https://microbiome.fudan.edu.cn/

Dr. Wu got his PhD degree in bioinformatics from James D. Watson Institute of Genome Sciences, Zhejiang University (2017-2012); worked as research assistant in Beijing Institute of Genomics, Chinese Academy of Sciences (2013-2014) and then had his postdoc training in Fredrik Bäckhed’s lab, University of Gothenburg, Sweden (2015-2020). He is now an independent PI in Human Phenome Institute, Fudan Microbiome Center, and Huashan Hospital, Fudan University.

His lab is mainly focused on studying the interactions between the gut microbes and us humans. To illustrate:

1）Gastrointestinal health and gut microbiota;
2）Microbial dysbiosis and incidence of various cardiometabolic diseases;
3）Diet- and drug- microbiota interactions;
4）Integration of multi-omics datasets;
5）Bacterial genomics and evolution.

•     Yudie Yang,Yize Ke,Xinyan Liu,Zhidong Zhang,Rongji Zhang, Fang Tian,Luqian Zhi,Guoping Zhao,Bomin Lv#,Sha Hua#,and Hao Wu#. Navigating the B vitamins: Dietary diversity,microbial synthesis, and human health. Cell Host & Microbe, 2024, doi.org/10.1016/j.chom.2023.12.004.

•    Sha Hua, Bomin Lv, Zeping Qiu, Zhuojin Li, Zhiyan Wang,  Yanjia Chen, Yanxin Han, Katherine L Tucker, Hao Wu#, Wei Jin#. Microbial metabolites in chronic heart failure and its common comorbidities. EMBO molecular medicine, 2023: e16928.

•    Wenlong Sun, Sha Hua, Xinyu Li, Liang Shen#, Hao Wu#, Hongfang Ji#. Microbially produced vitamin B12 contributes to the lipid-lowering effect of silymarin. Nat Commun, 2023, 14: 477.

•    Hao Wu*, Valentina Tremaroli*, Caroline, Schmidt, Annika Lundqvist, Lisa M Olsson, Anders Gummesson, Rosie Perkins, Göran Bergström#, Fredrik Bäckhed#. The gut microbiota in prediabetes and diabetes: a population-based cross-sectional study. Cell Metabolism. 2020. j.cmet.2020.06.011

•    Ara Koh, Antonio Molinaro, Marcus Ståhlman, Muhammad-Tanweer Khan, Caroline Schmidt, Hao Wu, Alba Carreras, Louise Olofsson, Louise Mannerås-Holm, Victor Gerdes, Annick Hartstra, Maurits de Brauw, Rosie Perkins, Max Nieuwdorp, Göran Bergström, Fredrik Bäckhed. Microbially produced imidazole propionate impairs insulin signaling through mTORC1. Cell. 2018. P947-961.E17

•    Adil Mardinoglu*, Hao Wu*, Elias Bjornson, Cheng Zhang, Antti Hakkarainen, Sari M. Räsänen, Sunjae Lee, Rosellina M. Mancina, Mattias Bergentall, Leonie Bogl, Kirsi H. Pietiläinen, Sanni Söderlund, Niina Matikainen, Marcus Ståhlman, Per-Olof Bergh, Martin Adiels, Brian D. Piening, Marit Granér, Nina Lundbom4, Kevin J. Williams, Stefano Romeo, Jens Nielsen, Michael Snyder, Mathias Uhlén, Göran Bergström, Rosie Perkins, Hanns-Ulrich Marschall, Fredrik Bäckhed, Marja-Riitta Taskinen and Jan Borén. Rapid metabolic benefits of a carbohydrate-restricted diet on hepatic steatosis associate with altered gut microbiome and increased folate production. Cell Metabolism. 2018: 559-571

•    Hao Wu*, Eduardo Esteve*, Valentina Tremaroli, Muhammad Tanweer Khan, Robert Caesar, Louise Mannerås-Holm, Marcus Ståhlman, Lisa M Olsson, Matteo Serino, Mercè Planas-Fèlix, Gemma Xifra, Josep M Mercader, David Torrents, Rémy Burcelin, Wifredo Ricart, Rosie Perkins, José Manuel Fernàndez-Real & Fredrik Bäckhed. Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug. 2017. Nature Medicine 23, 850–858 doi:10.1038/nm.4345

•    Hao Wu*, Valentina Tremaroli*, Fredrik Bäckhed. Linking Microbiota to Human Diseases: A Systems Biology Perspective. Trends in Endocrinology & Metabolism. 2015, DOI: j.tem.2015.09.011.