Joint PIs

03-2019 –  Current    Fudan University, professor
02-2011 – 03-2019    Institute Of Microbiology, Chinese Academy of Sciences, professor
07-2007 – 02-2011    University of Iowa, postdoc
10-2006 – 07-2007    The Wistar Institute, postdoc
09-2000 – 10-2006    Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
09-1995 – 07-1999    Southwest University (Chongqing, China)

The Huang laboratory focuses on studying the molecular mechanisms of morphogenesis, pathogenesis, and sexual reproduction in Candida species, major fungal pathogens of humans. Candida species such as C. albicans and C. tropicalis cause a number of infections in both immunocompetent and immunocompromised hosts. Reversible phenotypic transitions are associated with pathogenesis and sexual reproduction in these organisms. In the past several years, the Huang laboratory published over 40 scientific papers on environment-regulated morphological changes and sexual reproduction in C. albicans and other non-albicans species. These studies shed lights on the development of pathogenesis and antifungal resistance in pathogenic fungi.  

1.    Guan G, Tao L, Li C, Xu M, Liu L, Bennett RJ, Huang G. Glucose depletion enables Candida albicans mating independently of the epigenetic white-opaque switch. Nat Commun. 2023 Apr 12;14(1):2067.  
2.    Bing J, Guan Z, Zheng T, Zhang Z, Fan S, Ennis CL, Nobile CJ, Huang G. Clinical isolates of Candida auris with enhanced adherence and biofilm formation due to genomic amplification of ALS4. PLoS Pathog. 2023 Mar 13;19(3):e1011239.
3.    Guan G, Tao L, Yue H, Liang W, Gong J, Bing J, Zheng Q, Veri AO, Fan S, Robbins N, Cowen LE, Huang G. Environment-induced same-sex mating in the yeast Candida albicans through the Hsf1-Hsp90 pathway. PLoS Biol. 2019 Mar 13;17(3):e2006966.
4.    Yue H, Bing J, Zheng Q, Zhang Y, Hu T, Du H, Wang H, Huang G. Filamentation in Candida auris, an emerging fungal pathogen of humans: passage through the mammalian body induces a heritable phenotypic switch. Emerg Microbes Infect. 2018 Nov 28;7(1):188.
5.    Du H, Zheng Q, Bing J, Bennett RJ, Huang G. A coupled process of same- and opposite-sex mating generates polyploidy and genetic diversity in Candida tropicalis. PLoS Genet. 2018 May 7;14(5):e1007377.
6.    Tao L, Zhang Y, Fan S, Nobile CJ, Guan G, Huang G. Integration of the tricarboxylic acid (TCA) cycle with cAMP signaling and Sfl2 pathways in the regulation of CO2 sensing and hyphal development in Candida albicans. PLoS Genetics 2017 Aug 7;13(8):e1006949.
7.    Tao L, Du H, Guan G, Dai Y, Nobile CJ, Liang W, Cao C, Zhang Q, Zhong J, Huang G. Discovery of a "white-gray-opaque" tristable phenotypic switching system in candida albicans: roles of non-genetic diversity in host adaptation. PLoS Biol. 2014 Apr 1;12(4):e1001830.
8.    Xie J, Tao L, Nobile CJ, Tong Y, Guan G, Sun Y, Cao C, Hernday AD, Johnson AD, Zhang L, Bai FY, Huang G. White-opaque switching in natural MTLa/alpha isolates of Candida albicans: evolutionary implications for roles in host adaptation, pathogenesis, and sex. PLoS Biol. 2013;11(3):e1001525.