Joint PIs

2014.09-2020.07   University of Massachusetts Medical School, Postdoctoral Fellow

2006.09-2014.07   Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Ph.D. in Developmental Biology

2002.09-2006.07   Nanchang University, B.S. in Biology

Our main focus is on the interactions between bacteria and host. We mainly use Caenorhabditis elegans and its bacterial diet as a model system to study the molecular  mechanisms of how bacteria and their metabolites regulate the development, aging, and disease of the host.

1.Bhattacharya, S., Horowitz, B. B., Zhang, J., Li, X., Zhang, H., Giese, G. E., ... & Walhout,  A. J. (2022). A metabolic regulatory network for the Caenorhabditis elegansintestine. iscience, 25(8).

2. Walker, M. D., Giese, G. E., Holdorf, A. D., Bhattacharya, S., Diot, C., García-González, A.  P., ... & Walhout, A. J. (2021). WormPaths: Caenorhabditis elegans metabolic pathway  annotation and visualization. Genetics, 219(1), iyab089.

3. Zhang, J., Li, X., Olmedo, M., Holdorf, A. D., Shang, Y., Artal-Sanz, M., ... & Walhout, A.J.  (2019). A Delicate Balance between Bacterial Iron and Reactive Oxygen Species Supports  Optimal C. elegans Development. Cell Host & Microbe, 26(3), 400-411.

4.Zhang, J., Holdorf, A. D., & Walhout, A. J. (2017). C. elegans and its bacterial diet as a  model for systems-level understanding of host–microbiota interactions. Current Opinion in Biotechnology, 46, 74-80.

5.Guan, L., Ma, X., Zhang, J., Liu, J. J., Wang, Y., & Ding, M. (2016). The calponin family member CHDP-1 interacts with Rac/CED-10 to promote cell protrusions. PLoS Genetics, 12(7), e1006163.

6.Zhang, J., Li, X., Jevince, A. R., Guan, L., Wang, J., Hall, D. H., ... & Ding, M. (2013). Neuronal target identification requires  AHA-1-mediated fine-tuning of Wnt signaling in C. elegans. PLoS Genetics, 9(6), e1003618.