Joint PIs

11/2022-present    Principal Investigator, Institute of Pediatrics, Children’s Hospital of  Fudan University, Shanghai, China

09/2022-present    Principal Investigator, Institutes of Biomedical Sciences, Fudan  University, Shanghai, China

11/2018-07/2022   Associate Research Scientist, Department of Immunobiology, Yale University School of Medicine, Connecticut, USA

04/2016-10/2018   Postdoctoral Associate, Department of Immunobiology, Yale University School of Medicine, Connecticut, USA

Through technological innovation, the research group systematically studies human physiology (" how the human body maintains normal physiology ") and pathology (" how diseases occur "). We develop a series of high-throughput screening systems based on next generation sequencing for functional study of human and microbial metabolites. Identification and functional studies of orphan GPCR endogenous ligands; Systematization engineering of modern traditional Chinese medicine.

1. Chen H#, Rosen CE, Gonzalez-Hernandez JA, Song D, Potempa J, Ring AM, Palm NW#. Highly multiplexed bioactivity screening reveals human and microbiota metabolome-GPCRome interactions. Cell. 2023 Jul 6; 186(14):3095-3110 (# correspondence)

2. Yang Y, Nguyen M, Khetrapal V, Sonnert ND, Martin AL, Chen H, Martin AK, Palm NW. Within-host evolution of a gut pathobiont facilitates liver translocation. Nature. 2022 July; 607(7919): 563-570

3. Kim CS, Gatsios A, Guesta S, Lam YC, Wei Z, Chen H, Russell RM, Shine EE, Wang R, Wyche TP, Piizzi G, Flavell RA, Palm NW, Sperandio V, Crawford JM. Characterization of autoinducer-3 structure and biosynthesis in E.Coli. ACS Cent Sci. 2020 Feb 26; 6(2): 197-206

4. Oh J, Kim NY, Chen H, Palm NW, Crawford JM. An Ugi-like biosynthetic pathway encodes bombesin receptor subtype-3 agonists. J Am Chem Soc. 2019 Oct 16; 141(41): 16271-16278

5. Chen H, Nwe PK, Yang Y, Rosen CE, Bielecka AA, Kuchroo M, Cline GW, Kruse AC, Ring AM, Crawford JM, Palm NW. A forward chemical genetic screen reveals gut microbiota metabolites that modulate host physiology. Cell. 2019 May 16; 177(5): 1217-1231

6. Zhu S, Ding S, Wang P, Wei Z, Pan W, Palm NW, Yang Y, Yu H, Li HB, Wang G, Lei X, de Zoete MR, Zhao J, Zheng Y, Chen H, Zhao Y, Jurado KA, Feng N, Shan L, Kluger Y, Lu J, Abraham C, Fikrig E, Greenberg HB, Flavell RA. Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells. Nature. 2017 Jun 29; 546(7660): 667-670

7. Chen H, Yang Y, Xu H, Yang W, Zhai Z, Chen DY. Ring finger protein 166 potentiates RNA virus-induced interferon- production via enhancing the ubiquitination of TRAF3 and TRAF6. Sci Rep. 2015 Oct 12; 5: 14770

8. Li M, Di W, Xu H, Yang Y, Chen H, Zhang F, Zhai Z, Chen D. Negative regulation of RIG-I-mediated innate antiviral signaling by SEC14L1. J Virol. 2013 Sep; 87(18): 10037-46

9. Yang Z, Liang H, Zhou Q, Li Y, Chen H, Ye W, Chen D, Fleming J, Shu H, Liu Y. Crystal structure of ISG54 reveals a novel RNA binding structure and potential functional mechanisms. Cell Res. 2012 Sep; 22(9):1328-38

10. Yang Y, Qu H, Gao D, Di W, Chen H, Guo X, Zhai Z, Chen D. ARF-like protein 16 (ARL16) inhibits RIG-I by binding with its C-terminal domain in a GTP-dependent manner. J Biol Chem. 2011 Mar 25; 286(12): 10568-80