Joint PIs

2015.1-Present   Director and Prof., Center for Traditional Chinese Medicine and Gut Microbiota, Minhang hospital, Fudan University      

2009.10–2014.12 Prof. Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Shanghai Jiao Tong University School of Medicine    

2008.4 - 2009.9 Research Associate, Glasgow University, UK  

2004.3 - 2008.3 Associate Prof. Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Shanghai Jiao Tong University School of Medicine  

2001.7 - 2003.12 Research Assistant，BGI, Beijing

Focusing on the regulation of inflammation and immune response by gut microbiota and its clinical application. The main research contents include:

① Drawing on the prior experience of traditional Chinese medicine to develop new technologies for FMT; 

② Based on clinical practice, search for active substances that regulate inflammation and immune response from intestinal microbiota; 

③ Targeting gut microbiota, discover active substances regulating inflammation and immune response from classic Chinese medicine.

1. Han B, Li ZM, Zhao XY, Liang K, Mao YQ, Zhang SL, Huang LY, Kong CY, Peng X,  Chen HL, Huang JT, Yao JQ, Cai PR, Zhang ZY, Zhang XM, Yao ZJ, Chen GQ, Wang LS*. Annonaceous acetogenins mimic AA005 targets mitochondrial trifunctional enzyme alpha subunit to treat obesity in male mice. Nature Commun, 2024. Accepted.

2. Mao YQ, Huang JT, Zhang SL, Kong C, Li ZM, Jing H, Chen HL, Kong CY, Huang SH, Cai PR, Han B, Wang LS*. The antitumour effects of caloric restriction are mediated by the gut microbiome. Nat Metab. 2023 Jan 16. doi: 10.1038/s42255-022-00716-4.

3. Li ZM, Kong CY, Mao YQ, Chen HL, Zhang SL, Huang JT, Yao JQ, Cai PR, Xie N, Han B,Wang LS*. Host ALDH2 deficiency aggravates nonalcoholic steatohepatitis through gut-liver axis. Pharmacol Res. 2023;196:106902. doi: 10.1016/j.phrs.2023.106902.

4. Li ZM, Kong CY, Mao YQ, Huang JT, Chen HL, Han B, Wang LS. Ampicillin exacerbates acetaminophen-induced acute liver injury by inducing intestinal microbiota imbalance and butyrate reduction. Liver Int. 2023 Jan 10. doi: 10.1111/liv.15512.

5. Zhang SL, Han B, Mao YQ, Zhang ZY, Li ZM, Kong CY, Wu Y, Chen GQ, Wang LS*. Lacticaseibacillus paracasei sh2020 induced antitumor immunity and synergized with anti-programmed cell death 1 to reduce tumor burden in mice. Gut Microbes. 2022;14(1):2046246. doi: 10.1080/19490976.2022.2046246.

6. Zhang SL, Mao YQ, Zhang ZY, Li ZM, Kong CY, Chen HL, Cai PR, Han B, Wang LS*. Pectin supplement significantly enhanced anti-PD-1 efficiency in tumor-bearing mice humanized with gut microbiota from CRC patients. Theranostics, 2021;11(9):4155-4170.

7. Huang JT, Mao YQ, Han B, Zhang ZY, Chen HL. Li ZM, Kong CY, Xu JQ, Cai PR, Zeng YP, Zhao J, Zhao YP, Wang LS*. Calorie restriction conferred improvement effect on long-term rehabilitation of ischemic stroke via gut microbiota. Pharmacol Res. 2021;170:105726. doi: 10.1016/j.phrs.2021.105726.

8. Gao YY, Wu ZX, Xie LQ, Li CX, MYQ, Han B, Han SF, Lu HJ, Yang PY, Xia JL, Chen GQ*, Wang LS*. VHL deficiency augments anthracycline sensitivity of clear cell renal cell carcinomas by down-regulating ALDH2. Nature Commun, 2017, 15;8:15337. doi: 10.1038/ncomms15337.