Joint PIs

2025 - Current, Intelligent Medicine Institute, Fudan University, Professor

2019 - 2024, Michael Snyder Lab, Stanford University, Postdoctoral Fellow

2013 - 2019, UConn Health Center/The Jackson Laboratory, Ph.D. in Biomedical Science

2011 - 2013, Research Assistant

2007 - 2011, Fudan University, B.S. in Life Science

• Spearheaded the development of novel organoid and animal models to investigate the underlying  mechanisms of human immune and physiological responses to microbial agents.

• Engineered advanced AI algorithms for efficient microbial database mapping and collinearity analysis,  significantly enhancing pattern recognition and data integration.

• Led extensive multiomics analyses to decipher host responses to HERV-k in pulmonary arterial hypertension  (PAH) patients, generating new insights into disease mechanisms.

• Developed innovative statistical models for the rigorous analysis of microbial datasets, thereby improving  the accuracy and reliability of research findings.

1. Xin Zhou*, Xiaotao Shen*, Jethro S. Johnson, Daniel J. Spakowicz, Melissa Agnello, Wenyu Zhou, Monica Avina, Alexander  Honkala, Faye Chleilat, Shirley Jingyi Chen, Kexin Cha, Shana Leopold, Chenchen Zhu, Lei Chen, Lin Lyu, Daniel Hornburg,  Si Wu, Xinyue Zhang, Chao Jiang, Liuyiqi Jiang, Lihua Jiang, Ruiqi Jian, Andrew W. Brooks, Meng Wang, Kévin Contrepois,Peng Gao, Sophia Miryam Schüssler-Fiorenza Rose, Thi Dong Binh Tran, Hoan Nguyen, Alessandra Celli, Bo-Young Hong,  Eddy J. Bautista, Yair Dorsett, Paula Kavathas, Yanjiao Zhou, Erica Sodergren, George M. Weinstock, Michael P. Snyder.  Longitudinal profiling of the microbiome at four body sites reveals core stability and individualized dynamics during health  and diseases. Cell Host & Microbe, 2024, 32, 1-21

2. Daniel Hornburg, Si Wu, Mahdi Moqri, Xin Zhou, Kevin Contrepois, Nasim Bararpour, Gavin M. Traber, Baolong Su,  Ahmed A. Metwally, Monica Avina, Wenyu Zhou, Jessalyn M. Ubellacker, Tejaswini Mishra, Sophia Miryam Schüssler-Fiorenza Rose, Paula B. Kavathas, Kevin J. Williams, Michael P. Snyder. Dynamic lipidome alterations associated with  human health, disease and ageing. Nature Metabolism, 2023, 5(9): 1578–1594

3. Lin Lyu*, Xue Li*, Ru Feng*, Xin Zhou*, Xiaofei Yu, Guo Qiang Chen, Yufeng Ya, Tuhin K. Guha, Bing Su, Duowu Zou§,  Michael P. Snyder§, Lei Chen§. Simultaneous Profiling of Host Expression and Microbial Abundance by Spatial Meta  Transcriptome Sequencing. Genome Research. 2023, 33(3): 401-411

4. Zhiyun Yu*, Xin Zhou*, Ziyi Liu, Victor Pastrana-Gomez, Yu Liu, Minzhe Guo, Lei Tian, Timothy J. Nelson, Nian Wang,Seema Mital, David Chitayat, Joseph C. Wu, Marlene Rabinovitch, Sean M. Wu, Michael P. Snyder, Yifei Miao§, Mingxia  Gu§. Defect of KMT2D-mediated NOTCH Signaling Contributed to the Coronary Arterial Abnormalities in Hypoplastic Left  Heart Syndrome. Circulation Research. 2022. 131 (3), 280-282

5. Xin Zhou*, Jethro Johnson§, Daniel Spakowicz, Wenyu Zhou, Yanjiao Zhou, Erica Sodergren, Michael Snyder, George  Weinstock§. Longitudinal modeling of gut microbial abundance and serum cytokine levels links Clostridia with Th17 cell  activity in humans at risk for Type 2 diabetes. Diabetes, 2020. 69(8): 1833–1842

6. Wenyu Zhou*, M. Reza Sailani*, Kévin Contrepois*, Yanjiao Zhou*, Sara Ahadi*, [and 32 others, including Xin Zhou],  George M. Weinstock§, Michael Snyder§. Complex host-microbial dynamics in prediabetes revealed through longitudinal  multi-omics profiling. Nature, 2019; 569(7758), 663