Joint PIs

1) 01/2018 to present, PI/ Research Professor, National Clinical Research Center for Aging and Medicine, Fudan University

2) Since 12/2014, Associate Professor, Key Laboratory of Medical Molecular Virology, Ministry of Education, Fudan University

3) 01/2012 to 02/2013, Visiting Researcher, Institute of Biology and Chemistry of Protein, CNRS, France

4) 09/2009 to 11/2014, lecturer, Key Laboratory of Medical Molecular Virology, Ministry of Education, Fudan University

The research focuses on interaction between microbiota and host via co-metabolites, the molecular mechanism of infection immunity and aging from microbiota, developing original techniques for single-cell microbe for interactions in microbiota. He devoted himself to the mechanism and intervention strategy of aging from the perspective of the relationship between microbiota and host.

1.Yang H, Wang T, Qian C, Wang H, Yu D, Shi M, Fu M, Liu X, Pan M, Rong X, Xiao Z, Chen X, Yeerken A, Wu Y, Zheng Y, Yang H, Zhang M, Liu T, Qiao P, Qu Y, Lin Y, Huang Y, Jin J, Liu N, Wen Y, Sun N*, Zhao C*. Gut microbial-derived phenylacetylglutamine accelerates host cellular senescence. Nature Aging. 2025 Mar;5(3):401-418.

2. Wang, H., Rong, X., Zhao, G., Zhou, Y., Xiao, Y., Ma, D., Jin, X., Wu, Y., Yan, Y., Yang, H., Zhou, Y., Qian, M., Niu, C., Hu, X., Li, D.-Q., Liu, Q., Wen, Y., Jiang, Y.-Z.*, Zhao, C.*, Shao, Z.-M*.The microbial metabolite trimethylamine N-oxide promotes antitumor immunity in triple-negative breast cancer (2022) Cell Metabolism, 34 (4), pp. 581-594.e8. （featured, cover story, best paper in Cell Press, high cited）

3.Pan M, Qian C, Huo S, Wu Y, Zhao X, Ying Y, Wang B, Yang H, Yeerken A, Wang T, Fu M, Wang L, Wei Y, Zhao Y, Shao C*, Wang H*, Zhao C*. Gut-derived lactic acid enhances tryptophan to 5-hydroxytryptamine in regulation of anxiety via Akkermansia muciniphila. Gut Microbes. 2025;17(1):2447834. doi: 10.1080/19490976.2024.2447834.

4.Zhuang J, Wang Y, Wu X, Peng Z, Huang Z, Zhao C*, Shen B*. SIGMAR1 screened by a GPCR-related classifier regulates endoplasmic reticulum stress in bladder cancer. J Transl Med. 2025 Apr 10;23(1):417. doi: 10.1186/s12967-025-06393-7.

5. Wang L, Xu T, Wu S, Zhao C*, Huang H*. The efficacy and underlying mechanisms of berberine in the treatment of recurrent Clostridioides difficile infection. Int J Antimicrob Agents. 2025;65(5):107468. doi: 10.1016/j.ijantimicag.2025.107468.

6.Tong F, Yang H, Yu H, Sui LW, Yao JY, Shi CL, Yao QY, Shi MF, Qian CL, Li G*, Zhao C*, Wang HJ*. Protective and risk factors in daily life associated with cognitive decline of older adults. Front Aging Neurosci. 2025 Feb 26;17:1496677.