Liangdong Lyu-Fudan Microbiome Center

Liangdong Lyu

Position

Joint PI
Email

ld.lyu@fudan.edu.cn
Research Focus

Microbiome and infectious disease

Work Experience

2005-2011 Ph.D., Department of Microbiology, Fudan University;

2011-2015 Postdoctoral research in Shanghai Academy of Health Sciences, Chinese Academy of Sciences and Chinese University of Hong Kong;

2015-present doctoral supervisor of Fudan University, leader of the research group on the mechanism of persistent infection of Mycobacterium tuberculosis;

Since 2021, Distinguished Professor of Shanghai Clinical Medical Research Center for Infectious Diseases (Tuberculosis).

Research Interests

Taking clinically important pathogenic bacteria as the research object, basic and clinical related research is carried out around the mechanism of action of antibiotics, the formation mechanism of drug resistance and pathogenic mechanism.

Selected Publications

1. Cui Shujun,Chong Danyang,Wang Yi-Xin,Tong Huixian, Wang Minggui, Zhao Guo-Ping, Lyu Liang-Dong*. Fasting-induced Ketogenesis Sensitizes Bacteria to Antibiotic Treatment. Cell Metabolism. 2025 Apr 27: S1550-4131(25)00216-5. doi: 10.1016/j. cmet. 2025.04.006.

2. Deng Ming-Zhi, Liu Qingyun, Cui Shu-Jun, Wang Yi-Xin, Zhu Guoliang, Fu Han, Gan Mingyu, Xu Yuan-Yuan, Cai Xia, Wang Sheng, Sha Wei, Zhao Guo-Ping, Sarah M. Fortune, Lyu Liang-Dong*. An Additional Proofreader Contributes to DNA Replication Fidelity in Mycobacteria. PNAS. 2024, 121(34): e2322938121.

3. Wu Mengying,Shan Wenyan, Zhao Guo-Ping, Lyu Liang-Dong. H₂O₂ Concentration-Dependent Kinetics of Gene Expression: Linking the Intensity of Oxidative Stress and Mycobacterial Physiological Adaptation. Emerg Microbies Infec. 2022, 11(1):573-584.

4. Dong Wenyue, Nie Xiaoqun, Zhu Hong, Liu Qingyun, Shi Kunxiong, You Linlin, Zhang Yu, Fan Hongyan, Yan Bo, Niu Chen *, Lyu Liang-Dong*, Zhao Guo-Ping, Yang Chen*. Mycobacterial fatty acid catabolism is repressed by FdmR to sustain lipogenesis and virulence. PNAS. 2021. 118(16): e2019305118.

5. Fan Xiao-Yong, Tang Bi-Kui, Xu Yuan-Yuan, Han Ang-Xuan, Shi Kun-Xiong, Wu Yong-Kai, Ye Yu, Wei Mei-li, Niu Chen, Wong Ka-Wing, Zhao Guo-Ping*, and Lyu Liang-Dong*. Oxidation of dCTP contributes to antibiotic lethality in stationary-phase mycobacteria. PNAS. 2018,115(9): 2210-2215.

Position	Joint PI	Professor
Phone		Email	ld.lyu@fudan.edu.cn
Educational background		Research Focus	Microbiome and infectious disease

Joint PIs

Liangdong Lyu