Fudan Microbiome Center

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Fudan
Microbiome
Center

ABOUT F.M.C

Leveraging Fudan University's strengths in diverse disciplines such as life sciences, phenomics, materials and clinical resources, we drive interdisciplinary research, charting new paths and energizing microbiome studies.

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Publications

Title:: Navigating the B vitamins: Dietary diversity,microbial synthesis, and human health

Author:: Hao Wu

Brief Introduction:: B vitamins are intricately involved in various physiological processes vital for health. Their significance is complicated by the heterogeneous landscape of B vitamin distribution in diets and the contributions of the gut microbiota. Here, we delve into the impact of these factors on B vitamins and introduce strategies,with a focus on microbiota-based therapeutic options, to enhance their availability for improved well-being.Additionally, we provide an ecological and evolutionary perspective on the importance of B vitamins to hu man-microbiota interactions. In the dynamic realms of nutrition and microbiome science, these essential mi cronutrients continue to play a fundamental role in our understanding of disease development.

Title:: Metagenomic characterization of a novel non-ammonia-oxidizing Thaumarchaeota from hadal sediment

Author:: Zhexue Quan

Brief Introduction:: Background The hadal sediment, found at an ocean depth of more than 6000 m, is geographically isolated and under extremely high hydrostatic pressure, resulting in a unique ecosystem. Thaumarchaeota are ubiquitous marine microorganisms predominantly present in hadal environments. While there have been several studies on Thaumarchaeota there, most of them have primarily focused on ammonia-oxidizing archaea (AOA). However, systematic metagenomic research specifcally targeting heterotrophic non-AOA Thaumarchaeota is lacking.

Title:: Current Challenges and Future Directions for Human Gut Microbiome Researches

Author:: Hao Wu, Sofa Forslund, Zeneng Wang, Guoping Zhao

Brief Introduction:: Eight selected challenges we are facing in human gut microbiome researches. ① Defining the healthy and core gut microbiome;② Unveiling bacterial strain differences and functional diversity; ③Robust gut bacteria profiling: DNA and RNA; ④ Culturing the 'yet-unculturable'; ⑤ From association to causal studies; ⑥ From intra- tointer-kingdom interactions; ⑦ From bench to bedside; ⑧ From microbiome to phenome and precision medicine